| 1. | 
	 (satellite adjective) difficult to treat or deal with; "stubborn rust stains"; "a stubborn case of acne"   | 
	
	
	
	
	
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         | 2. | 
	 (adjective) tenaciously unwilling or marked by tenacious unwillingness to yield   | 
	
	
	
	
	
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	 Antonyms: docile | 
	
	
	
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         | 3. | 
	 (satellite adjective) persisting in a reactionary stand   | 
	
	
	
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	 Synonyms: obstinate, unregenerate | 
	
        
	
	
	
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         | 4. | 
	 (satellite adjective) (med) not responding to treatment; "a stubborn infection"; "a refractory case of acne"    | 
	
	
	
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	 Synonyms: refractory | 
	
        
	
	
	
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